I also wholeheartedly recommend Fullmetal Alchemist. Alchemy, martial arts, family relationships, complex moral questions, a tightly-woven plot, and a diverse group of SERIOUSLY kickass female characters.
The first anime is good, but I think the SERIOUSLY kickass female character quotient kicks up a few notches in the manga.
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The first anime is good, but I think the SERIOUSLY kickass female character quotient kicks up a few notches in the manga.